Ida Grayson shows up in Curtis Wells to meet up with her husband, but the proprietor of the hotel refuses to rent her a room because of her skin color. While leaving town, she and her driver are set on by robbers, and are saved by Newt Call and Buffalo Bill in the nick of time. Call takes her back to town, where no one will help her. The next day, he again takes her to the Lonesome Dove, where he and a newcomer, Clay Mosby, are forced to get violent with some racist locals while they ensure her a room.
Curtis Wells is cut off from the rest of the world until the snow clears in the passes. Newt and Kearny rescue a group of minors lost in the mountains and near frozen to death. Mosby and Newt come to blows over Hannah, but are forced to fight together when the miners turn out to be a ruthless gang of criminals.