The Dixon brothers, T-Dog, Jacqui, as well as Morales and his family are not characters in the comic book, although they are each featured prominently in season 1 of the TV series.
Out of the 20 characters at the camp, only 10 are actually in the comic (Rick Lori, Carl, Shane, Carol, Sophia, Jim, Dale, Andrea, Amy and Glenn).
The story takes place during the "Days Gone By" (which the pilot is also called) arc (issues 1-6).
"Walking Dead" creator Robert Kirkman was on the set throughout the filming of the first season.
This is the second AMC show to feature a Winnebago. In the show "Breaking Bad", a bigger model is used throughout the show.
The name Edwin Jenner, the doctor at the CDC, is a reference to to Edward Jenner who developed the first vaccine.
During lunch breaks, the zombie cast would eat together while the human cast ate together.
Actors who played zombies had to go through zombie school to learn how to walk and move like zombies.
In an online interview, it was revealed that Frank Darabont envisioned having several self-contained episodes that would not continue the main story. One such episode would have been the season two premiere. It would have involved Sam Witwer (who Darabont used in The Mist and played the tank zombie in the series premiere) as a solider in a Black Hawk Down style Atlanta. Witwer would have encountered several of the cast before being bit and locking himself in the tank.