An assassin named Al Simmons is double-crossed and murdered by his evil boss Jason Wynn. Al makes a deal with the devil and returns to earth as Spawn to see his wife. He is ordered by the devil's minion, The Clown, to kill Wynn. Wynn has made a deal with the clown too and is suppose to destroy the world with a deadly virus that will help start Armageddon and allow Hell to attack Heaven. Spawn must choose between Good & Evil.
In the series finale, Twitch remembers that Chief Banks shot him. When Twitch confronts Banks, he takes his own life rather than confessing his crime. At Al's grave, Jade confesses to Spawn that since she saved him, Heaven now has a bounty on her head. Two new Celestial Warriors appear and battle Spawn and Jade. Spawn visits Cyan's sick Granny and grants her desire to visit Jack, her dead husband.