Many lawyers consider themselves prophets, but Eli Stone may be the real deal. Eli has built a successful career at a top law firm in San Francisco representing only the biggest and richest corporations that make a habit of screwing over the little guy. But after experiencing a series of odd hallucinations, Eli seeks to find a deeper meaning to life while trying not to lose his job and destroy his relationship with the bosses' daughter. When Eli discovers an aneurysm in his brain, he wonders if his condition is truly medical or if perhaps he now has a higher calling.
The firm tries to force devout parents to donate their daughter's heart to an atheist, and Eli's vision of another plane crash causes him to risk the Dark Truth again, but the death he sees is unexpected.