Deep Blue Sea is a 1999 science fiction horror film directed by Renny Harlin and written by Duncan Kennedy, Donna Powers, and Wayne Powers. It stars Thomas Jane, Saffron Burrows, Samuel L. Jackson, Michael Rapaport and LL Cool J. The film follows a team of scientists in an isolated underwater facility who are researching the brains of mako sharks to help fight Alzheimer's, only for the sharks to go on a rampage after two of the scientists, Susan McAlester and Jim Whitlock, genetically enhance their intelligence in secret. An international co-production between the United States and Mexico, Deep Blue Sea represented a test for Harlin, who had not made a commercially successful film since Cliffhanger (1993). The film was primarily shot at Fox Baja Studios in Rosarito, where the production team constructed sets above the large water tanks that had been built for James Cameron's Titanic (1997).