Slither is a 2006 science fiction body horror comedy film written and directed by James Gunn in his directorial debut. The film stars Nathan Fillion, Elizabeth Banks, Tania Saulnier, Gregg Henry, and Michael Rooker. Its plot follows the residents of a small town in South Carolina that becomes invaded by a malevolent alien parasite. Slither was theatrically released in the United States and Canada on March 31, 2006, by Universal Pictures and TVA Films respectively.