Splice is a 2009 science fiction horror film directed by Vincenzo Natali, and starring Adrien Brody, Sarah Polley, and Delphine Chanéac. The story concerns experiments in genetic engineering being done by a young scientific couple, who attempt to introduce human DNA into their work of splicing animal genes resulting in the creation of a human–animal hybrid. Steve Hoban served as producer, while Guillermo del Toro, Don Murphy, Susan Montford, Christophe Riandee, Yvis Chevalier, and Sidonie Dumas served as the original executive producers. The film premiered at the 2009 Sitges Film Festival, before the US distriubtion rights were bought by Joel Silver's Dark Castle Entertainment in partnership with Warner Bros.