Masters of the Air is based on Donald L. Miller's nonfiction novel Masters of the Air: America's Bomber Boys Who Fought the Air War Against Nazi Germany and follows the aerial wars in WWII through the eyes of men of the Eighth Air Force, also known as the Mighty Eighth, who brought the war to Hitler's doorstep.

Led by Majors Cleven and Egan, the 100th Bomb Group arrives in England and joins the 8th Air Force's campaign against Nazi Germany.

The 100th bombs German U-boat pens in Norway. With the help of Lt. Crosby's navigating, a damaged B-17 struggles to get back to Britain.

The group participates in its largest mission to date—the bombing of vital aircraft manufacturing plants deep within Germany.

Lt. Rosenthal joins the 100th just as one of its crews reaches a milestone. The U-boat pens at Bremen become a target for the second time.

Rosie's next mission signals a significant shift in the 100th's bombing strategy. Crosby receives a promotion, but it comes with a high price.

Rosie and his crew are sent to rest at a country estate. Crosby meets an intriguing British officer at Oxford. Egan faces the essence of Nazi evil.

The prisoners of Stalag Luft III attempt to connect with the outside world. Berlin becomes the 100th's primary target. Rosie makes a crucial decision.

Crosby prepares for D-Day. The POWs wonder how the Allied landing will affect their fate. Tuskegee pilots attack targets in Southern France.

Series finale. The POWs are marched across Germany—and Rosie makes a gruesome discovery—as the war comes to its conclusion.