
Lincoln Burrows is currently on death row and scheduled to die in a few months for an assassination his younger brother Michael is convinced he did not commit. With no other options and time winding down, Michael takes drastic measures to get himself incarcerated alongside his brother in Fox River State Penitentiary. Once he's inside, Michael - a structural engineer with the blueprints for the prison - begins to execute an elaborate plan to break Lincoln out and prove him innocent. When Michael arrives at Fox River State Penitentiary, he meets the prison denizens who will, unknowingly, help in his escape plans - his cellmate, the lovelorn Sucre; beautiful prison doctor Dr. Sara Tancredi, who happens to be the governor's daughter; former mob boss John Abruzzi; and Warden Henry Pope. Meanwhile, outside the prison walls, the brothers' childhood friend and Lincoln's lost love, attorney Veronica Donovan, works within the law to free them; Lincoln's teenage son LJ may be going down a path similar to his convicted father's; and Secret Service Agent Paul Kellerman's investigation into Lincoln's case proves that there may be a national conspiracy.
Dominic Purcell Lincoln "Linc" Burrows
Wentworth Miller Michael Scofield
Robert Knepper Theodore "T-Bag" Bagwell
Amaury Nolasco Fernando Sucre
Sarah Wayne Callies Sara Tancredi
Wade Williams Brad Bellick
William Fichtner Alexander "Alex" Mahone
Paul Adelstein Paul Kellerman
Rockmond Dunbar Benjamin Miles "C-Note" Franklin
Jodi Lyn O'Keefe Gretchen Morgan
Marshall Allman LJ Burrows
Robin Tunney Veronica Donovan