Butcher's Block , the third installment of the Channel Zero anthology series introduces us to Alice Woods and her schizophrenic sister Zoe who have moved to a small town to start over. Alice lives in constant fear of inheriting Zoe's illness. On the outskirts of town lies Butcher's Block, a hellish neighborhood where junkies roam and lawlessness abounds. It is here the sisters encounter Joseph Peach and his eerily charismatic family. The Peach's are not your ordinary family; they live above the Butcher's Block in a dimension that is dark utopia. They offer the sisters a place at their table with promise of a world without worry and without illness. The sisters soon find that the cost of living the good life comes at an unimaginable price and there is a fine line between escaping insanity and embracing true madness.

Alice and Zoe Woods move away from their mother to the city of Garret, and Alice takes a job as a social worker in "Butcher's Block", a rundown part of the city. She soon discovers a mystery when a mother and daughter disappear, and the mystery seems connected to nearby Medallion Park... which is haunted by a staircase that goes nowhere.

Zoe returns to the house strangely changed. Meanwhile, Luke arrests one of the Peaches, who has a snack in his cell. And Alice and Louise continue pursuing the mystery of the disappearances.

After Zoe cuts her leg shaving, Alice takes her to the hospital. Louise, Luke, and Nathan go with her and encounter Robert.

Luke makes a critical mistake after taking Robert's body to Louise. Meanwhile, Alice goes through the door and tries to find Zoe, who is having lunch with the Peaches.

Alice embraces the Peaches to avoid insanity, and Zoe tries to convince her to leave after learning that Izzy is "marked".

The landlord makes his entrance, and nothing will be the same when the Peaches fail to present Izzy as the sacrifice. Despite Zoe's efforts, Alice looks into the God's universe.