Dr. Will Halstead (Nick Gehlfuss) balances the stress of being an emergency medicine physician with his complicated relationship with Dr. Natalie Manning (Torrey DeVitto), a specialist in emergency pediatrics. Newly widowed, Dr. Daniel Charles (Oliver Platt) remains the Sherlock Holmes of psychiatry. Former Navy flight surgeon Dr. Ethan Choi (Brian Tee) brings his battlefield skills to the front lines of Chicago's busiest ER, the go-to place for victims of the city's gun violence. Work and personal life intersect with him and April Sexton (Yaya DaCosta), a smart, bold and intuitive nurse with the ability to adeptly tackle the most harried of circumstances in the hospital. Sharon Goodwin (S. Epatha Merkerson), the venerable head of the city's largest hospital, is under intense fiscal scrutiny to preserve the bottom line while continuing to ensure that all patients receive nothing short of quality care and compassion. Maggie Lockwood (Marlyne Barrett), the charge nurse and eyes, ears and brain of the ER, is skilled and confident but finds herself dealing with profound family issues of her own. Recent addition to the ER is ace surgeon Dr. Crockett Marcel (Dominic Rains), a New Orleans-raised surgeon whose breezy manner hides a tragic past. Together they will confront Chicago's most critical medical cases and challenging ethical dilemmas with courage, compassion and state-of-the-art treatment. "Chicago Med" will weave cutting-edge medicine with the personal drama that comes with working in such a high-intensity environment. Through it all, familiar faces from "Chicago Fire" and "Chicago P.D." will intertwine with Chicago's finest medical heroes.

The entire staff at Chicago Med adjusts to the new normal of the pandemic. Dr. Choi, Dr. Lanik and April fight on the front lines. Dr. Halstead and Hannah face a troubling reality. Dr. Charles tries to clear the air with his daughter following recent developments.

Goodwin announces a new ED Chief and the choice doesn't make everyone happy. Dr. Manning takes a stand for her patient and finds herself dealing with the repercussions. Dr. Charles tends to family affairs.

Dr. Charles and April team up to take on a mysterious patient in the ED. Dr. Halstead is forced to make a life-or-death decision for one of his trial patients. Dr. Marcel is confronted by his past when a former acquaintance is brought into the ED.

Dr. Marcel and Dr. Manning lay everything on the line to assist a sick woman. Dr. Halstead faces an uphill battle in getting participants involved in his clinical trial. Dr. Choi clashes with a patient who demands absolute perfection of himself.

Dr. Halstead finds continued success in his trial. Dr. Charles' daughter, Anna, receives life-changing news. Noah finds himself in a situation not even April can fix.

Dr. Choi helps a patient with chronic pain find a solution. Dr. Halstead considers a new path. Dr. Charles and Anna bond over a scary situation.

Will runs into trouble when one of his trial patients falls ill. His own stress and symptoms have Ethan struggling to get through the day.

Ethan hires an old Navy colleague to join him in the ED. A final custody hearing threatens to separate Charles and his daughter. Maggie must make a choice that will change Auggie's life.

As Maggie deals with her own trauma, she steps in to help a mother in need. Dean continues to stir the pot with more than one doctor. A patient comes to Med needing immediate treatment, but doesn't want it from them.

Crockett deals with a patient who ends up having more in common with him than he thinks. Will and Ethan clash over a pregnant patient with an irregular heartbeat.

Choi teams up with an unexpected person to treat a famous tennis player who is afraid his career might be over. Goodwin's new protocols cause a stir.

Dean and Ethan respond to a scene that brings back some bad memories. When Carol's condition worsens, Natalie is willing to do whatever it takes to get her mom feeling better.

An auto accident sends Goodwin into a spiral as she tries to help a young boy and his mother. Natalie's secretive behavior begins to draw the attention of Dr. Marcel and Dr. Halstead.

Third-year med students begin their rotation in the ED and Maggie keeps a careful eye on one of them. Natalie, whose mom's health takes another decline, tries to cover up how she broke the rules to treat her.

Crockett worries he made a surgical error when a recent transplant patient comes in with complications. Carol is once again in distress. Will and Natalie must take action to right their wrong.

Carol receives a second chance at life when a new heart becomes available. Ethan and Dean find themselves in hot water with an old patient. Will faces the consequences of the stolen trial medication.