Ashley Humphrey and her husband, a bodybuilder, are the prime suspects in the July 2003 murder of Sandra Rozzo, a Florida bartender.
Larissa Schuster, a biochemist, is accused of hiring James Fagone for killing her estranged husband Timothy Schuster in July 2003, then disposing of his body.
Cynthia Sommer, a military wife, is suspected of murdering her husband Todd in February 2002 when his autopsy reveals he was poisoned with arsenic.
Mechele Linehan's fiance Kent Leppink is gunned down in the Alaskan wilderness in May 1996, and ten years later she is charged in the murder.
Beth Carpenter had a promising law career, but when her brother-in-law Buzz Clinton found dead on a highway in March 1994, she becomes the prime suspect.
Monique Johnson, a prison guard, shoots her boyfriend, Memphis police officer Tony Hayes, to death in September 2006, but claims he was abusive.
Susan Grund, a mother of two, is accused of shooting her husband, attorney Jimmy Grund, in the couple's Peru, Indiana home in August 1992.
Lisa Costello and her boyfriend, Alan Mackerley, are charged with murder after the February 1996 disappearance of Alan's business rival, Frank Black.
Jocelyn Dooley is charged with murder after police locate the body of her husband, pit boss, Vol "Bubba" Dooley in June 2001.
Renee Poole's husband Brent is gunned down on his wedding anniversary in June 1998, and police suspect his wife plotted the murder.
Nikki Reynolds pleads guilty after stabbing her adoptive mother, Billie Jean, to death in May 1997.
Jennifer Hyatte is a prison nurse turned fugitive after fatally shooting a prison guard in August 2005.
Rhonda Orr's husband died in a house fire in May 2003, and she becomes suspected of arson when police learn that she is pregnant with another man's child.
Erin McLean was a student teacher whose husband Eric McLean murdered 18 year-old dropout Sean Powell in March 2007.
Shannon Torrez is desperate for a baby, and in September 2006, she stabs a mother in her home and then kidnaps the woman's one-week-old daughter.
Monique Turenne is accused of soliciting her lover to bludgeon her husband, Canadian Air Force Major David Turenne, in February 1996.
Kelly Forbes is accused of strangling her newlywed husband to death in November 2007, and then claims self-defense.
When Michelle Michael called 911, saying her husband had shot himself, it was quickly clear that her story was not credible. Supersized with additional footage.
Jill Rockcastle, a poker player's wife, stabs her husband to death in April 2007 in their Las Vegas condominium.
Denise Miller is suspected of killing her on-again, off-again boyfriend, police officer Wayne Irby, in December 2004 after a bitter breakup.
Tracie Andrews is the prime suspect in the December 1996 stabbing death of her fiance, Lee Harvey, in a road rage incident.
Anne Marie Stout's husband is shot dead in their home in June 2007, and she is charged with his murder.
Rhonda Glover, a Texas beauty queen, is charged in the July 2004 shooting death of her satanic boyfriend in his Austin, Texas home.
Karen Tobie and her neighbor Lynne Blake orchestrate the shooting death of Karen's husband, plumber John Cataneo, in June 2004.
Jane Andrews, the former aide to the Dutchess of York, bludgeons and stabs her lover, Tom Cressman, to death in September 2000.
Diane Fleming is suspected of poisoning her third husband with methanol after his mysterious death in June 2000, but she maintains that she is innocent.
Elicia Hughes is suspected of shooting her husband, Brian, in their home in June 2004 after learning of his infidelity. Supersized with additional footage.