
Extremely ruthless and ambitious cardinal Rodrigo Borgia uses bribery to take advantage of the death of the current Pope and rise to the Papacy.

Micheletto, Orsini's assassin is recruited by Cesare to defect into the service of Della Rovere who is trying to prove Rodrigo has taken on a mistress.

Rodrigo seeks funds through a profitable marriage for Lucrezia and charges a fee for safe haven; the Borgias host a Turkish prince.

Lucrezia's wedding is a disaster; the Borgia children's mother arrives; Della Rovere seeks the aid of the Medici family.

Lucrezia has an affair with a stable boy; Cesare strikes a bargain with Machiavelli and takes action to rid Ursula of her husband.

Della Rovere strikes a bargain with King Charles of France; Rodrigo attempts to thwart an invasion.

The invasion of France proceeds; Giovanni Sforza is poised to join the battle; Leonardo Da Vinci shares drawings and blueprints.

The invaders capture a pregnant Lucrezia who charms King Charles; Pope Alexander VI awaits his fate.

Alexander meets King Charles with humility; Charles abandons Della Rovere; Lucrezia gives birth in a convent.