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With his eyes fixed on the future, Watson faces an unexpected twist when Sherlock Holmes, who was presumed dead, resurfaces, forcing him to confront a buried secret from his past—one that lies hidden within his own body.
Episodes
1. A Son in the Oven
Watson and the fellows spring back into action when Mary's mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed; Sherlock Holmes resurfaces after being presumed dead.
2. Back from the Dead
When a microbiology university researcher returns from an expedition to Siberia, she and her team members fall ill from a possible revived pathogen; Watson catches up with his friend Sherlock Holmes after finding out he is alive.
3. Expletive Deleted
Watson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10.
4. Happy When It Rains
Watson and the team jump into action when four people become infected with what seems like a flesh-eating bacterium; Shinwell searches for meaning as a nursing student; Adam's wedding to Lauren risks being halted.
5. Lucky
While visiting another hospital, Watson becomes convinced that a man is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade; Sherlock is back in town and is staying with Watson.
6. Buying Time
Watson and the fellows race against time to save the life of Casey, a 21-year-old athlete with a fast-growing, seemingly incurable cancer. Meanwhile, Mycroft Holmes lets Watson know his team's work at UHOP may no longer have funding available.
7. Giant Steps
Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts.
8. Livvy Sees The Doctor
Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter's illness.
9. Shannon Says Bex Loves Micah
Watson and the fellows help Laila's son Micah, who was injured in a car accident while pursuing his crush, Bex, with the help of his AI chatbot.
10. Never Been CRISPR'd
Watson's biohacker friend Hobie (aka the man with the glowing chest) returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong. Meanwhile, Watson becomes suspicious of Sherlock.
11. The Tunnel Under the Elms
Watson and the fellows race against the clock to save a man and his pregnant wife from a terrifying sinkhole. Meanwhile, Ingrid's future with her therapy group becomes unclear.
12. A Family Meal
When a patient arrives at the Holmes Clinic plagued by a mysterious neurological disorder, Watson and the fellows discover they were forced to eat their parents amid a childhood survival incident. Meanwhile, Adam is struggling with how his future will change as a father.
13. For a Limited Time Only
Watson and the fellows fight to revive a 30-year-old woman, Audrey, after her heart stops and she experiences a rare phenomenon called Lazarus syndrome. As these revivals continue, she uses the short window of time available to right her greatest wrong.
14. Wrongful Life
Watson is sued for Wrongful Life by a long-term patient suffering from VACTERL association, after undergoing multiple painful surgeries.
15. A Third Act Surprise
Watson and the fellows race to save the life of a young woman who needs a lifesaving kidney donation. Meanwhile, Sherlock returns to help crack unsolved cases in Pittsburgh.
16. Respect the Process. Respect the Quirks
Watson investigates a case involving a mentally unstable mother, with the woman's delusions serving as a mirror to his own newly discovered hallucinations.
17. Unsolved Mysteries
The team works with Sherlock on a mysterious case, related to Watson's past.
18. Sic Semper Tyrannis
Following his brain tumor diagnosis, Watson goes on medical leave to seek treatment, leaving Mary in charge of The Holmes Clinic as a notorious South American dictator demands Watson see to his mysterious autoimmune condition personally. Meanwhile, Ingrid grows more concerned about Beck's obsession with Sasha.
19. The Rule of Three
As Adam's wife goes in for a C-section to deliver triplets, chaos ensues when their OB-GYN passes out in the operating room. Meanwhile, a severe storm detours Watson and Mary's trip to find a renowned doctor to remove Watson's brain tumor.
20. The Cobalt Fissure
A seemingly random murder outside of UHOP sets the stage for the arrival of someone from Watson and Sherlock Holmes' past.